New light on neuronal ATP-sensitive potassium channels / 中国药理学通报
Chinese Pharmacological Bulletin
; (12)2003.
Article
in Zh
| WPRIM
| ID: wpr-678429
Responsible library:
WPRO
ABSTRACT
ATP sensitive potassium (K ATP ) channels widely expressed in many tissue and cell types including neurons are heteromultimers of sulfonylurea receptor (SUR) and inward rectifier K + channel (Kir6) subunits associated with 1∶1 stoichiometry as a tetramer (SUR/Kir6) 4. The activity of K ATP channels is modulated by intracellular ATP concentrations. Neuronal K ATP channels are involved in the mediation of glucose sensing and metabolic stress. Under physiological condition, they also possess important pathophysiological functions in acute brain ischemic and chronic neurodegenerative diseases.
Full text:
1
Index:
WPRIM
Type of study:
Diagnostic_studies
Language:
Zh
Journal:
Chinese Pharmacological Bulletin
Year:
2003
Type:
Article