Enhancement effect of propofol on binding function of GABA_A receptor / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12)2001.
Article
in Chinese
| WPRIM
| ID: wpr-678557
ABSTRACT
Objective:
To investigate the influence of propofol on the binding function of GABA A receptor.Methods:
By using radioligand receptor binding assay, effects of propofol on the specific binding of 3H GABA and saturation curves of GABA A receptor were observed in cortical membrane preparations from mouse cerebral cortex.Results:
Specific binding experiments showed that propofol at the concentrations of 10 300 ?mol/L markedly enhanced the specific binding of 3H GABA( P 0.05).Conclusion:
Clinical concentrations of propofol can enhance the binding function of GABA A receptor through increasing the affinity of the low affinity binding site of GABA.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Academic Journal of Second Military Medical University
Year:
2001
Type:
Article
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