Responses of urinary bladder detrusor to neurotransmitters in aged rats / 第三军医大学学报

ABSTRACT

Objective To study the neurogenic mechanism of urinary bladder dysfunction changes in the aged rats. Methods Wistar rats were divided into aged group (24 month old) and young adult group (6 month old, served as the control group). The reactivity of urinary detrusor strips in the two groups to different concentrations of carbachol, noradrenalin, isoproterenol, adenosine triphosphate (ATP) and atropin, was measured respectively using an in vitro tissue bath technique. Results Compared with the young adult rats, significantly increased relaxation response to high concentration of isoproterenol and contractile response to ATP were found in aged rats. No difference in responses to carbachol, atropin and noradrenalin was found in the aged rats. Conclusion The dysfunction in aging bladder may be related to the purinergic and ? adrenergic response modifications.