?_3-adrenergic-receptor gene polymorphism in type 2 diabetic retinopathy in Chinese / 第二军医大学学报

ABSTRACT

Objective:To observe the relationship between diabetic retinopathy (DR) and ? 3 adrenergic receptor (? 3 AR) gene polymorphism in Chinese patients with type 2 diabetes mellitus. Methods: The mutation of genotype of Trp64Arg in ? 3 AR gene was measured wit h PCR RFLP in 50 normal control and 196 patients with type 2 diabetes, while other clinical parameters [body mass index (BMI), blood pressure, fasting blood glucose, serum lipid levels and HbA1c] were all measured. Results: (1)There were no significant differences in the freque ncies of ? 3 AR phenotypes and alleles between type 2 diabetic patients and n ormal controls or between female patients and male patients; (2) The plasma triglyceride, diastolic blood pressure and BMI in female patients with mutation of ? 3 AR gene were higher than those in without mutation. There was no difference in male diabetic patients; (3)There was no difference in genotype frequencies or allele frequencies between diabetic patients with or without retinopathy. Genotype and allele frequencies didnot differ in proliferative diabetic retinopathy and non proliferative diabetic retinopathy. Conclusion: The mutation of Trp64Arg in ? 3 AR gene is associated with obesity, hypertension and dyslipideamia in femal e diabetic patients. Trp64Arg polymorphism in ? 3 AR gene is not associated with diabetic retinopathy in type 2 diabetes mellitus patients in Shanghai.