Pharmacokinetics of honokiol in rats / 北京大学学报(医学版)

ABSTRACT

Objective: To investigate the pharmacokinetics of honokiol in rats. Methods: Honokiol injection was delivered by vein injection to SD rats. The blood samples were gathered at a series of time lags. Honokiol in rat plasma was determined with an RP HPLC method and the data were analyzed with program 3P87. Results: After i v injection of honokiol, concentration time curves were fitted to a 3 compartment model with halftime of 2.8 min, 11.9 min, and 56.8 min. Conclusion: Honokiol was quickly distributed in rats after i.v. and the concentration decreased rapidly. Our studies provided important referrence to the research on the pharmacodynamics and the pharmaceutics of Honokiol.