Urothelial carcinoma in patients with chronic aristolochic acid nephropathy / 中华肾脏病杂志

ABSTRACT

Objective To investigate the urothelial carcinoma in patients with chronic aristolochic acid nephropathy(CAAN). Methods The clinical data of urothelial carcinoma were analyzed in 4 cases among 102 patients with CAAN. Results (1)Chronic renal insufficiency caused by CAAN was diagnosed in 4 patients after intermittently taking the medicine containing aristolochic acid(AA) for a long time (from 3 years to 24 years). (2) Urinary examination of these 4 cases showed the red cells with uniformed shape. Two of them experienced an episode of macroscopic haematuria. (3) Three of them had papillary transitional cell carcinomas on the bladder wall by the cystoscopy and pathological examination. The other one had carcinoma of the left renal pelvis by the retrograde urography and pathological examination after surgical operation. Conclusion CAAN is associated with the developing urothelial tumours when a patient with CAAN has an episode of macroscopic or obvious microscopic hematuria with red cells of uniformed shape.