Growth suppression effect of ~(131)I-labeled anti-KDR monoclonal antibody on tumor tissue of human bladder cancer subcutaneously implanted in SCID mice / 第三军医大学学报

ABSTRACT

Objective To study the growth suppression effect of 131 I labeled anti KDR monoclonal antibody on the tumor tissue of human bladder cancer subcutaneously implanted in SCID mice. Methods The SCID murine model was established by subcutaneous implantation of human bladder cancer in mice. The 131 I labeled anti KDR monoclonal antibody (3G9) was injected into the caudal vein of mice (experimental group). The anti KDR monoclonal antibodies and saline were injected into the caudal vein of the mice (control group and blank group, respectively). The growth suppression effect of 131 I labeled anti KDR monoclonal antibody on the tumor tissue of SCID mice bearing human bladder cancer was observed. Results Tumor tissue necrosis was found in the mice of the experimental group and the control group at 3 weeks after the injection. Compared with that in the blank group, the growth suppression ratio in the experimental group and the control group were 96.8% and 87.7%, respectively. Conclusion 131 I labeled anti KDR monoclonal antibody may be of potential clinical significance in the anti angiogenesis therapy for human cancer.