The relationship between therapeutic effects and concentration in tissue or serum of Mel G / 中国药理学通报

ABSTRACT

Aim To study the effects of Meloxicam gel(Mel G)on AA in rats,and the relationship between therapeutic effects and Mel G in tissue or serum. Methods The model of AA was induced by intradermal injection of Freunds complete adjuvant(FCA) in rats,the effects(hindpaw swelling volume)of Mel G on AA rats were observed following Mel G tc. A high performance liquid chromatography(HPLC)method with ultraviolet detection was set up to determine the concentration of Mel in serum and local tissue. Results Mel G significantly inhibited secondary inflammation of AA rats. The concentration of Mel G was lower in serum and higher in local tissue than that of Mel tablets. A significant linear correlation in a negative manner existed between local tissue concentration of Mel G and hindpaw swelling volume. Conclusion Therapeutic effects of Mel G on AA in rats were associated with higher tissue concentration of Mel G.