Clinical effect of consensus interferon in the retreatment of previous nonresponders or relapsers of chronic hepatitis C / 中华传染病杂志
Chinese Journal of Infectious Diseases
;
(12)2001.
Article
in Chinese
| WPRIM
| ID: wpr-679137
ABSTRACT
Objective To evaluate the efficacy and safety of consensus interferon in previous nonresponders or relapsers of chronic hepatitis C as well as to compare the correlation between viral kinetics and the efficacy. Methods 32 patients who are previous nonresponders or relapsers to IFN received CIFN 15?g three times a week for 24 weeks. Efficacy was assessed by ALT and HCV RNA (viral kinetics) during the 24 weeks of treatment period and 6 month follow up post treatment. Results After 24 weeks treatment, HCV RNA negative rate in the previous nonresponders and the previous relapsers were 90% versus 45.5% ( P 0.05 ). The major adverse events were fever and leukopenia. Conclusions CIFN 15?g as a monotherapy significantly improved end of treatment response rate in chronic hepatitis C patients. Baseline serum HCV RNA load and early virus kinetics are predictive parameters of SR.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Infectious Diseases
Year:
2001
Type:
Article
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