Deactivation of medial prefrontal and posterior cingulate cortex in anxiety disorders / 中华放射学杂志

ABSTRACT

Objective We used blood oxygenation level dependent-functional MR imaging(BOLD- fMRI)to explore the characteristics of deactivation patterns in patients with anxiety disorders and the underlying neural mechanism of this disease.Methods Ten patients and ten healthy controls participated the experiments.All subjects performed the trait portion of the State-Trait anxiety Inventory(STAI-T)prior to the fMRI scans.The subjects underwent noninvasive functional magnetic resonance imaging while listening actively to emotionally neutral words alternating with no words(experiment 1)and threat related-words alternating with emotionally neutral words(experiment2).During fMRI scanning,subjects were instructed to closely listen to each stimuli word and to silently make a judgment of the word's valence.Data were analyzed with statistical parametric mapping(SPM 99).Individual and group analysis were conducted.Results Mean STAI-T score was significantly higher for patients group than that of controls(58?8 for patients group and 33?5 for controls,t=8.3,P