Combined use of recombinant human growth hormone and intensive insulin therapy in the treatment of severely burned patients / 解放军医学杂志

ABSTRACT

Objective To observe the effect of recombinant human growth hormone(rhGH)combined with intensive insulin therapy on the metabolism in severely burned patients.Methods From March 2001 to October 2007,15 severely burned patients were enrolled in the study,and they were categorized as rhGH combined with intensive insulin group(group I,n=6)and rhGH with insulin in ordinary dose group(group R,n=9).The excised burn wounds were closed with microautograft and allograft skin within 4 days after burn injury.Postoperatively,all patients received rhGH every night for 14 days.In group R,insulin in ordinary dose was added to glucose infusion,and in group I,an insulin pump was used to control blood glucose at 4-8mmol/L.Blood samples were collected for determination of blood glucose,K+,serum amino acid profile,and proalbumin,and urinary 3-MH were also measured.Results The concentration of blood glucose,K+,blood amino acids and urinary 3-MH in group I became lower than that in group R 3 days after surgery(P