The influence of erythropoietin to the ultrastructure of retinal neurons and content of retinal glutamate in the early stage diabetic rats / 眼科
Ophthalmology in China
;
(6)1993.
Article
in Chinese
| WPRIM
| ID: wpr-680449
ABSTRACT
Objective To investigate the efficacy of recombinant human erythropoietin(rhEPO)in preventing and reversing dys- function of retinal neurons in streptozotocin(STZ)-induced diabetes in rats.Design Experimental study.Participants The early stage of diabetic rats.Method Two weeks after STZ(60 mg/kg,i.p.),diabetic rats were administered rhEPO(5000IU/kg)injection three times weekly for 2 weeks.Retinal samples of STZ-induced diabetic rats with or without rhEPO and controls were prepared for ultrathin sec- tions and subsequently photography by transmission electron microscope.Also the content of glutamate in retina of the rats was detected with high-performance liquid chromatography.Main Outcome Measures The ultrastructure of rat retinas and the content of retinal glutamate.Results Mitochondrial metamorphosis in ganglion cells occurred in STZ-induced diabetic rats without rhEPO.Obvious mito- chondrial metamorphosis couldn′t be found in STZ-induced diabetic rats with rhEPO treatment.Retinal glutamate at the end of the 4th week of STZ-induced diabetic rats had increased obviously comparing with the normal rats(P
Full text:
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Ophthalmology in China
Year:
1993
Type:
Article
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