Inhibitory effect of KANGXIANLING containing serum on ex-vivo proliferation of human hepato carcinoma cell HepG_2 / 中草药

ABSTRACT

Object To study the antitumor action of KANGXIANLING (KXL), a traditional herbal preparation and its mechanism of action at molecular pharmacological level. Methods Effect of KXL containing serum on cell periferation and protein expression of P 21 WAF1/CIP1 of human hepatic cancer HepG 2 were studied by serologic pharmacologic tests. Results KXL containing serum at concentrations of 18, 9, 3 g/kg inhibited proliferation of ex vivo cultured HepG 2 cells by (63.09?5.08)%,(55.09?4.09)%, and (48.08?4.08)% respectively. Their cytotoxicities were (48.06?4.08)%, (38.09?5.01)%, and ( 25.00? 4.13)% respectively, which were all higher than that of blank serum without KXL (P