Simulation and experimentation of separation condition of Ginkgolic Acids / 中成药

ABSTRACT

Objective: To optimize extraction conditions to completely separate ginkgolic acids off ginkgolic flavonone glycosides and terpene lactones. Methods: A liquid liquid equilibrium model was used to simulate extracting process of active components in ginkgo biloba leaves. Results of calculation and experiment were compared to value the extraction system, and the best extracting condition was established. Results: when pH=2.5, extractant consists of 20% ethanol water solution and cyclo hexane, the best extraction efficient can be obtained. Conclusion: There is a great difference between theoretical simulating distribution ratio and experiment value in order of magnitude. However, their relative relationship is consistent.