The Effects of a Single Bolus of Remifentanil on Corrected QT Interval Change during Sevoflurane Induction
Yonsei Medical Journal
;
: 333-338, 2011.
Article
in English
| WPRIM
| ID: wpr-68171
ABSTRACT
PURPOSE:
Opioids may affect changes in the corrected QT interval (QTc) during anesthetic induction. This study examine whether a single bolus of remifentanil would prolong QTc after laryngeal mask airway (LMA) insertion during sevoflurane induction. MATERIALS ANDMETHODS:
Forty women of American Society of Anesthesiologists physical status 1 (ASA PS1) undergoing gynecological surgery were studied. All patients were induced using three vital capacity inhalation inductions with 5% sevoflurane. Two minutes after induction, the inspiratory concentration of sevoflurane was reduced to 2%. Using double-blinded randomization, patients were allocated into one of two groups, receiving either saline (placebo group, n = 20) or 0.25 microg.kg-1 remifentanil (remifentanil group, n = 20) over a period of thirty seconds. Sixty seconds later, LMA insertion was performed. Recordings were taken with a 12-lead electrocardiogram at baseline, 2 min after induction and 1 and 3 min after LMA insertion. QTc was calculated by Bazett's formula. The mean arterial pressure (MAP) and heart rate (HR) were also measured at each time point.RESULTS:
The QTc interval was significantly prolonged in the placebo group as compared to the remifentanil group at 1 min after LMA insertion (467.8 +/- 16.5 vs. 442.7 +/- 21.3 ms, p < 0.001). However, there was no significant difference in QTc at 3 min after LMA insertion between the two groups. MAP and HR were significantly higher in the placebo group (p < 0.001).CONCLUSION:
A single bolus of remifentanil is safe method to attenuate prolonged QTc associated with insertion of LMA.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Piperidines
/
Gynecologic Surgical Procedures
/
Anesthetics, Intravenous
/
Anesthetics, Inhalation
/
Electrocardiography
/
Heart Rate
/
Methyl Ethers
Type of study:
Controlled clinical trial
Limits:
Adult
/
Female
/
Humans
Language:
English
Journal:
Yonsei Medical Journal
Year:
2011
Type:
Article
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