Pharmacokinetical study on Sini Decoction / 中成药
Chinese Traditional Patent Medicine
;
(12)1992.
Article
in Chinese
| WPRIM
| ID: wpr-681794
ABSTRACT
Objective:
To study the correlation of pharmacokinetics(PK) and pharmacodynamics(PD) of Sini Decoction (SND) (Radix Aconiti Praeparata, Rhizoma Zingiberis, Radix Glycyrrhizae, etc.) and reveal the compatibility of SND.Methods:
Using the drug serums from the same source, we determined the plasma concentration in vivo in dog and the pharmacological effects at the same time inspected by the contents of aconitine type alkaloids and nitric oxide (NO).Results:
The data of PK and PD can be both described by one compartment open model with first order absorption in vivo in dog and the parameters of two methods are similar. The results show that the effective fraction of SND gives a prompt and lasting effect in accordance with characteristic function of SND.Conclusion:
A good correlation exists in SND of the parameters between pharmacokinetics and pharmacodynamics.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Traditional Patent Medicine
Year:
1992
Type:
Article
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