Effect of Kangqianling Granules on renal fibrosis in chronic renal failure / 中成药
Chinese Traditional Patent Medicine
;
(12)1992.
Article
in Chinese
| WPRIM
| ID: wpr-682214
ABSTRACT
Objective:
To observe the effect of Kangqianling Granules (Radix Salviae miltiorrhizae,Radix et Rhizoma Rhei, Radix Achyranthis Bidentatae, etc.) on renal function and renal fibrosis in chronic renal faiure(CRF).Methods:
Effect of Kangqianling Granules on Serum Creatinine (SCR), Blood Urea Nitrogen (BUN), Laminin (LN), Fibronectin (FN), Precollagen Ⅲ (PC Ⅲ) and Collagen Ⅳ (C Ⅳ) were observed in CRF patients and rats with 5/6 nephrectomy. The expression of FN and C Ⅳ in remnent renal tissue of model rats were determined by immunhistochemistry.Results:
Kangqianling Granules decreased significently serum volume for Scr, BUN, LN, PC Ⅲ, C Ⅳ and elevated FN considerably in CRF patients and rats. Kangqianling Granules inhibited the expressions of FN and C Ⅳ protein in remnant renal tissue of model rats.Conclusion:
Kangqianling Granules could relieve renal fibrosis and delay process of CRF.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional Patent Medicine
Year:
1992
Type:
Article
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