Effects of essential oil from Radix Angelicae Sinensis on rat uterine contraction in vitro / 中成药
Chinese Traditional Patent Medicine
;
(12)1992.
Article
in Chinese
| WPRIM
| ID: wpr-682348
ABSTRACT
AIM:
To investigate the contraction effect of essential oil of Radix Angelicae Sinensis on isolated uterus in rats.METHODS:
Isolated uterine strips of rats were used to observe the reactions in the presence of oxytocine and high k + depolarization solution.RESULTS:
The isolated rat uterus contraction induced by oxytocin and Ca 2+ after high K + depolarization was dose dependently inhibited by the essential oil. The cumulative dose response curves of CaCl 2 shifted to right and the maximal responses were depressed. This showed that the essential oil was a non competitive antagonist. The extracellular and intracellular Ca 2+ dependent contraction evoked by oxytocin could also be inhibited by the essential oil.CONCLUSION:
The essential oil of Radix Angelicae Sinensis could inhibit the contractility of the isolated uteri, and it might act as an Ca 2+ antagonist to relax the isolated rat uterus.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional Patent Medicine
Year:
1992
Type:
Article
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