Correlation between the abnormal expression of ICAM-1 and CD44s and lymph node metastasis in human non small cell lung cancer / 中华胸心血管外科杂志

ABSTRACT

Objective: To study the mRNA and protein expressions of ICAM 1 and CD44s in non small cell lung cancer as well as nearby normal lung tissue. Methods: RT PCR and SP immunohistochemistry were used to detect the mRNA and protein expressions of ICAM 1 and CD44s in 42 non small cell lung cancer and nearby normal lung tissue. Results: The expression level of ICAM 1 and CD44s increased in NSCLC tissue than in normal tissue. No correlations were noted in expression of ICAM 1 and CD44s and pathological type, histological differentiation and TNM stage. But there was significant correlation between abnormal expressions of ICAM 1 and CD44s and lymph node metastasis. Conclusion: These results suggest that the level of ICAM 1 and CD44s genes expression in lung cells increases as they progress from normal to the transformed stage, that indicate these two genes are involved in the process of lung cancer development.