TLC and HPLC quantitative determination for Xiao'er Ganmao Granules / 中成药

ABSTRACT

AIM: To establish a method for the quality control of Xiao'er Ganmao Granules(Flos Chrysanthemi, Radix Cynanchi Atrati, Cortex Lycii, etc.). METHODS: Radix Cynanchi Atrati, Cortex Lycii and Flos Chrysanthemi were identified by TLC. The forsythin content in Xiao'er Ganmao Granules was determinated by HPLC. RESULTS: The methodological study showed that a good linear correlation for the forsythin existed in a range of 4.76～588ng. The average recovery of forsythin ( n =9) was 98.7% and RSD was 1.7%. CONCLUSION: The method is simple, accurate and with good repeating and high precision, and can be used for quality control of Xiao'er Ganmao Granules.