Therapeutic Effect of Shukou Powder for Experimental Periodontitis in Rats / 广州中医药大学学报

ABSTRACT

[Objective] To observe the therapeutic effect of Shukou Powder (SP) for experimental periodontitis in rats. [Methods] Seventy-five SD rats were randomized into five groups normal, model, iodine glycerin (20 g/L), high-dose SP (200 g/L) and low-dose SP (100 g/L). The experimental periodontitis rat models were established by ligating molars with steel wire combined with intramuscularly injection of prednisolone (1.25mg, 8 times). Except that the model and normal groups were treated by applying saline, the other groups were treated by applying the corresponding drugs 0.5 mL to the peridentium, tid for 10 days. After treatment, debris index, probe depth and bleeding rate during probing were investigated and the pathological changes of periodontal tissues were also observed. [ Results ] Bleeding rate during probing decreased in high- and low-dose SP groups, debris index decreased in high-dose SP group, the difference being significant (P