Two Cases of HLA-B59(+) Stevens-Johnson Syndrome (SJS)-Toxic Epidermal Necrolysis (TEN) Associated with Methazolamide Treatment / 대한피부과학회지
Korean Journal of Dermatology
;
: 561-563, 2005.
Article
in Korean
| WPRIM
| ID: wpr-68290
ABSTRACT
Methazolamide is a sulfonamide derivative and carbonic anhydrase inhibitor used to lower intraocular pressure in glaucomatous eyes. Stevens-Johnson syndrome (SJS)-toxic epidermal necrolysis (TEN) associated with methazolamide treatment has been reported in Korean and Japanese patients. We report two cases of SJS-TEN associated with methazolamide treatment. The result of HLA typing of our two patients was a positive reaction for HLA-B59, which is specific to Koreans and Japanese. This suggests a possible relationship between genetic background and SJS-TEN associated with methazolamide treatment. Therefore, methazolamide should be prescribed with caution to Korean or Japanese patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Histocompatibility Testing
/
Stevens-Johnson Syndrome
/
Carbonic Anhydrases
/
Asian People
/
Intraocular Pressure
/
Methazolamide
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Dermatology
Year:
2005
Type:
Article
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