The association between ankylosing spondylitis with polymorphism in -308 site of TNF-?promoter region:the Meta analysis / 中华风湿病学杂志
Chinese Journal of Rheumatology
;
(12)2000.
Article
in Chinese
| WPRIM
| ID: wpr-683145
ABSTRACT
Objective To explore the association between ankylosing spondylitis(AS)with the poly- morphism in -308 site of tumor necrosis factor(TNF)-?promoter region. Methods The literature about AS and polymorphism in -308 site of TNF-?promoter region were searched and the meta analysis as performed. Results Eight studies enrolled 987 AS patients and 922 controls in total. The analysis showed that the fre- quencies of alleles and the genotypes had no statistical difference between AS group and the control group [OR=0.86(0.53, 1.38), P=0.53; OR=0.90(0.52, 1.55), P=0.69]. But the frequencies of alleles of western origin had statistical difference between AS group and the control group [OR=0.75(0.59, 0.96), P=0.02]; The TNF-?gene promoter polymorphism may play a role in the severity of sacroiliitis[OR=0.37(0.15. 0.90), P=0.03]. Conclusion The meta-analysis reveales that the alleles of -308 site of TNF-?promoter region may be associated with AS in western ethnical group and play a role in the severity of saeroiliitis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Systematic reviews
Language:
Chinese
Journal:
Chinese Journal of Rheumatology
Year:
2000
Type:
Article
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