Effect of bcl-xi overexpression in transgene mice with cerebral infarction and study of cytochrome Cexpression and caspase-3 expression / 中华急诊医学杂志
Chinese Journal of Emergency Medicine
; (12)2006.
Article
in Zh
| WPRIM
| ID: wpr-683305
Responsible library:
WPRO
ABSTRACT
0.05).At different time points after ischemia-reperfusion,the expression of cytochrome C and activation of caspase-3 were lower in the transgen mice than that in the wild type rats.Conclusions Under standard condition,overexpression of bcl-xl could significantly reduce the infarct area and improve neurological function in transgene mice than those in the wild type rats.The effect of overexpression of bcl-xl might be realized through inhibiting the apoptosis of neuron,and the mechanism might be that the overexpression of bcl-xl inhibit the release of cytochrome C and the activation of caspase-3.
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Index:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Emergency Medicine
Year:
2006
Type:
Article