Effect of iipopclysaccharide on ENaC expression in the lung of rats with acute lung injured / 中华急诊医学杂志
Chinese Journal of Emergency Medicine
; (12)2006.
Article
in Zh
| WPRIM
| ID: wpr-683357
Responsible library:
WPRO
ABSTRACT
Objective To study the effect of lipopolysaccharide(LPS)on the endo-pulmonary natrium channel(ENaC)expression in the lung of rats with acute lung injured.Method Sixteen rats were randomly divided into normal control group and LPS-group.Rats of normal control group and LPS-group were killed at 6 hours after intravenous injection of normal saline(8 ml/kg)or LPS(8 mg/kg).The extent of lung injury was assessed by arterial blood gas analysis and histological examination.At the same time,?-ENaC protein and???- ENaC mRNA expression in the lung tissue were analyzed by immunohistochemistry and RT-PCR.Results PaO_2 in LPS-group was noticeably lower than in normal control group(P
Full text:
1
Index:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Emergency Medicine
Year:
2006
Type:
Article