Effects of bererine on basolateral potassium current of rat colonic crypt cells / 中华消化杂志
Chinese Journal of Digestion
; (12)2001.
Article
in Zh
| WPRIM
| ID: wpr-683440
Responsible library:
WPRO
ABSTRACT
Objective To investigate the effects of berberine on basolateral calcium-activated potassium current I_K(Ca)and cAMP-activated potassium current I_K(cAMP)and its mechanism in treatment of secretory diarrhea.Methods The intact colonic crypt cells were isolated with EDTA solution.The effects of berberine(50,100,500?mol/L)on I_K(Ca)and I_K(cAMP)were detected by patch clamp technique under the conventional whole cell patch clamp mode.The solution of PSS was served as control.Results Berberine could significantly inhibite I_K(Ca)and I_K(cAMP)of rat colonic crypt cells(both P
Full text:
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Index:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Digestion
Year:
2001
Type:
Article