The effect of yemazhui on concentration of levofloxacin in rinse solution of mice tracheae / 重庆医科大学学报

ABSTRACT

Objective:To study the effect of yemazhui on concentration of levofloxacin in rinse solution of mice tracheae. Methods:50 mice were randomly divided into blank group、anwhlor group、yemazhui large-dose group、yemazhui middle-dose group, yemazhui low-dose group, each group had 10 mice. After administration of liquor natrii chloridi isotonicus (NS) 30 ml/10kg, amchlor1.00g/kg、yemazhui large dose 64.45g (curde drug)/kg、yemazhui middle dose 32.73g (curde drug)/kg, yemazhui low dose16.36g(curde drug)/kg, mice were intraperitoneal injected levofloxaein at dosage of 0.07g/kg 2hours after administration. The concentration of levofloxacin in excretion of mice tracheae was detected by HPLC. Results:Comparion with blank group, concentration of levofloxacin in excretion of mice tracheae of yemazhui large-dose group、yemazhui middle-dose group、yemazhui low-dose group was 4.58 times、3.18 times、1.86 times the amout of that. Conclusion:Yemazhui can enhance concentration of lwvofloxacin in rinse solution of mice tracheae.