Itraconazole injection for treatment of fungal infections in the patients with hematological malignancies / 重庆医科大学学报
Journal of Chongqing Medical University
;
(12)2003.
Article
in Chinese
| WPRIM
| ID: wpr-683612
ABSTRACT
Objective:
To evaluate the efficacy and safety of itraconazole in the treatment of fungal infection in the patients with hematological malignancies.Method:
53 patients with malignant hematologic diseases were divided into three groupsempirical treatment group, suspected fungal infection group and established group.Itraconazole was given in a dose of 200mg twice daily in the first and the second days, from the third day in a dose of 200mg once daily.Response was established as normalization of temperature in the patients receiving itraconazole, and disappearance of clinical signs in the patients with suspected or established infection.Result:
The 31 patients were eligible for efficacy evaluation for empirical treatment,and 25 responded to itraconazole(80.65%);of 9 established patients,6 responded to itraconazole(66.67%);of 13 suspected infection patients, 10 responded to itraconazole(76.92%).As to the side effects, there were no rigor and fever, but hepatotoxiciy were present in 5.66%, and no nephrotoxicity.Conclusion:
Itraconazole is a highly effective drug with low side effects in treatment of fungal infections.But the hepatic and renal function tests must be carried out regularly when itraconazole infection is used.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Chongqing Medical University
Year:
2003
Type:
Article
Similar
MEDLINE
...
LILACS
LIS