Biosynthesis, Biotechnological Production and Applications of 5-Aminolevulinic acid / 微生物学通报

ABSTRACT

Microbial production of 5-aminolevulinic acid (5-ALA) by photosynthetic bacteria compared to other bacteria and algae was reviewed. During anaerobic cultivation of the Rhodobacter spaeroides mutant strain, control of the redox potential was effective or producing large amounts of extracellular ALA. ALA has been practically applied in agriculture as herbicide, pesticide and growth-promoting factor for plants. New agriculture applications including salt tolerance and cold temperature tolerance of plants were also desired. Finally recent medical application for cancer treatment, tumor diagnosis and other clinical uses were discussed.