Novel Role of Invariant Natural Killer T-cell in Glycemic Control: Regulation by human Adenovirus 36
Journal of Bacteriology and Virology
;
: 229-232, 2013.
Article
in Korean
| WPRIM
| ID: wpr-68531
ABSTRACT
Obesity is associated with a state of chronic low-grade inflammation. This abnormal inflammation state may cause metabolic dysfunction. Many studies have supported the claim that immune cells such as adipose tissue macrophage and invariant natural killer T-cells (iNKT) are related to the development of metabolic diseases like diabetes. It has recently been reported that while human adenovirus 36 (Ad36) infection is associated with human obesity, it also helps to improve the serum level of lipid factors (glycemic control). However, the detailed cellular mechanism remains unclear. This study (The Journal of Clinical Investigation, 2012;1223343-54) showed that iNKT cell-deficient mice on a low-fat diet used as a control for high-fat diet boasted insulin resistance phenotype without adipose tissue inflammation. The results of this study offer insight into the possibility of a novel role for iNKT related to the improvement of metabolic diseases, especially insulin resistance, and hint that Ad36-induced inflammation may be associated with iNKT in adipose tissue, while also playing a role in the improvement of glycemic control.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenotype
/
Insulin Resistance
/
Adenoviruses, Human
/
Adipose Tissue
/
Diet, Fat-Restricted
/
Natural Killer T-Cells
/
Diet, High-Fat
/
Inflammation
/
Macrophages
/
Metabolic Diseases
Limits:
Animals
/
Humans
Language:
Korean
Journal:
Journal of Bacteriology and Virology
Year:
2013
Type:
Article
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