Telmisartan Prevent Oxidative Injuries in Endothelial Cells Induced by High Glucose / 中华高血压杂志
Chinese Journal of Hypertension
; (12)2007.
Article
in Zh
| WPRIM
| ID: wpr-685817
Responsible library:
WPRO
ABSTRACT
Objective To investigate the effect of telmisartan on the oxidative stress induced by high glucose in human umbilical vein endothelial cell (HUVEC) in vitro.Methods HUVEC were cocultured with telmisartan (1?10~(-6) mol/L) and various concentration of glucose(5,30 mmol/L) for 0,12,24,36,48 h respectively. The level of MDA in the supernatants of cultured endothelial cells was measured by thiobarbituric acid test,SOD was determined by xanthine oxidase test.The protein expression of peroxisome proliferator activated receptors ? (PPAR-?) in HUVEC 24 h was assessed by Western blot after treatments.Results High glucose significantly increase the levels of MDA (before:1.2?0.06 vs after:1.6?0.1 mmol/mL,P
Full text:
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Index:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Hypertension
Year:
2007
Type:
Article