The Role of Androgen in High-Salt Induced Hypertension in Rats / 中华高血压杂志

ABSTRACT

Objective To study the effects of high salt intake on blood pressure and renin-angiotensin in male rats with different plasm androgen levels.Methods Thirty male Wistar rats were randomized to sham(n=10)or operated(n=10),or castration(n=10),or testosterone replacement after castarion(26.7 mg/kg,n=10)and fed with 8% NaCl for 8 weeks.Tall arterial pressure were recorded before,4 and 8 weeks after experiment.Serum PRA,plasma angiotensin Ⅱ(Ang Ⅱ)and testosterone(T)were determined by radioimmunoassey respectively. Results After 8 weeks high salt dietary,blood pressure was significantly increased in sham and testosterone replace ment rats(Sham operation group137.3?4.0 vs the basal line117.5?5.9 mmHg,testosterone replacement group 134.4?5.2 vs the basal line116.6?7.7 mmHg,P0.05).Concomitantly,sham operation or testosterone re placement rats had higher PRA and plasm Ang Ⅱ content compared with castrated rats(PRASham operation 5.90 ?0.77 vs testosterone replacement group5.69?0.47 vs castrated rats4.90?0.55 mol/(L?h),P