Impact of symptom and gastric accommodation of combination therapy in patients with functional dyspepsia / 重庆医学

ABSTRACT

Objective To study the impact of symptom score ,gastric emptying test and gastric accommodation of compound az-intamide(CA) combined with mosapride(MSP) drugs in patients with functional dyspepsia(FD) .Methods From February 2012 to March 2013 ,112 cases of hospital patients with FD were divided into the observation group (56 cases) and the control group (56 cases) .The control group was given MSP for treatment ,while the observation group was given MSP and CA .The curative effect , symptom scores and gastric accommodation ,as well as gastric emptying test results condition before and after treatment of two groups were Compared .Results The effective rate and the total effective rate of observation group were 51 .79% ,80 .36% ,which were significantly higher than the control group(32 .14% ,51 .79% )(P<0 .05) ;the improvement rate of the observation group was 8 .93% ,which was significantly lower than the control group 25 .00% (P<0 .05) .After treatment ,the observation group′s symp-tom score was (8 .7 ± 6 .3)points ,which was significantly lower than before treatment (22 .4 ± 7 .9)points ,and the control group af-ter treatment (12 .7 ± 3 .6) points ;the maximum amount of drinking water was (387 .1 ± 105 .8)mL ,which was significantly higher than the pre-treatment of (320 .8 ± 90 .9)mL ,and the control group after treatment of (351 .3 ± 77 .7)mL ;After treatment ,2 h full gastric emptying rate was 66 .07% (37/56) ,5 h full gastric emptying rate was 94 .64% (53/56) ,which were significantly higher than before treatment of 10 .71% (6/56) ,23 .21% (13/56) ,and the control group after treatment of 44 .64% (25/56) ,73 .21% (41/56) ,the differences were statistically significant (P<0 .05) .Conclusion CA combined MSP treat FD can significantly improve pa-tient symptoms ,promote gastric emptying ,and increase patients′gastric accommodation .The effect is significant and is worthy of recommendation .