INSULIN RESISTANCE IN MIDDLE AGED MONGOLIANS AND ITS RELATIONSHIPS WITH CARDIOMETABOLIC RISK / Шинэ санаа Шинэ нээлт

ABSTRACT

@#BACKGROUND Insulin resistance is the state of organs being resistant to insulin resulting in decrease of glucose utility. Insulin resistance is tightly interconnected to metabolic syndrome and cardiovascular disease risk factors. However, among Mongolian population, study on insulin resistance is rare. METHODS The aim of the study was to evaluate the prevalence of insulin resistance (IR) and its relationships with cardiometabolic risk factors in middle aged Mongolians. In 149 men and women we measured carbohydrate and lipid metabolism parameters, obesity markers, blood pressure, high sensitive C-reactive protein and uric acid levels. IR was determined by the HOMA-IR index. The threshold level of HOMA-IR proved to be 2.8 conv. units. The frequency of IR detection by HOMA-IR index was 43.0%. We identified risk factors that were most closely associated with the presence of IR. They were metabolic syndrome by International Diabetes Federation (2005) criteria, diastolic blood pressure and C-reactive protein level. RESULTS Study covered 149 men and women with average age of 49.5. HOMA-IR index average was 2.2. The threshold HOMA-IR index was 2.8. The IR prevalence was high at 43% without any gender difference. CONCLUSION The threshold HOMA-IR index was 2.8 in the study participants. Moreover, cardiovascular risk factors according to SCORE criteria were high. High blood pressure, C-reactive protein, and having metabolic syndrome increases IR risk by 2-3 times. As a result of the study, diagnosing obesity using WHO criteria of BMI>30kg/m2 rather than WPRO criteria of BMI>25 kg/m2 is statistically more significant.