Anti-inflammatory activity and wound healing effect of the gingita® natural essential oils mouth wash in rats / Шинэ санаа Шинэ нээлт

ABSTRACT

@#Essential oils have evoked interest as sources of natural products, which their potential uses an alternative remedies for the treatment of many infectious disease and to restore healing mouth sores or kill oral bacteria. Gum disease is one of the major factor for systemic disease, which to recommend the latest study of world medical scientist. This study aimed to evaluate the anti-inflammatory activity and wound healing effect of the GINGITA® natural essential oils mouth wash in rats. Treatment was by topical application of the GINGITA® natural essential oils mouth wash onto wound surface for 21 days. Wistar rats divided into 2 groups of 15 animals each and anesthesia was administered. The dorsal area of skin of the each rats was shaved and clipped fully-thickness 10x10mm skin wound was made. The test group was treated with GINGITA® natural essential oils mouth wash, which control group untreated. A better healing pattern was observed in rats treated with GINGITA® natural essential oils mouth wash compared with the control group. There was a significant reduction in wound length and closure rats was faster treated by GINGITA® natural essential oils mouth wash compared with control group. Immunohistochemical analysis demonstrated that an increase of epithelial cells in wound lesions treated with GINGITA® natural essential oils mouth wash wish as compared untreated control group. Conclusions: The present study revealed that GINGITA® natural essential oils mouth wash may be effective in stimulating the enclosure of wounds in sort period time.