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Association between Perceived Stressfulness of Stressful Life Events and the Suicidal Risk in Chinese Patients with Major Depressive Disorder / 中华医学杂志(英文版)
Chinese Medical Journal ; (24): 912-919, 2018.
Article in English | WPRIM | ID: wpr-687009
ABSTRACT
<p><b>Background</b>Patients with major depressive disorder (MDD) usually have high risk of suicidality. Few studies have investigated the effects of stressful life events (SLEs) on the risk of suicide in Chinese patients who have developed MDD. This study aimed to investigate the impact of SLEs on suicidal risk in Chinese patients with MDD.</p><p><b>Methods</b>In total, 1029 patients with MDD were included from nine psychiatric hospitals to evaluate the impact of SLEs on suicidal risk. Patients fulfilling the Mini-International Neuropsychiatric Interview (MINI) criteria for MDD were included in the study. Patients were excluded if they had lifetime or current diagnoses of psychotic disorder, bipolar disorder, and alcohol or substance dependence. Depressive symptoms were assessed by the 17-item Hamilton Depression Scale (HAMD-17). The suicidal risk of MDD patients was determined by the suicide risk module of MINI. SLEs were assessed by the Life Events Scale.</p><p><b>Results</b>No gender difference was found for suicidal risk in MDD patients. Patients with suicidal risk had younger ages, lower education levels, more drinking behavior, and lower marriage rate, and fewer people had child and more severe depressive symptoms than nonsuicidal risk group. High-level perceived stressfulness (HPS) and number of SLEs that patients were exposed to were significantly greater in patients with suicidal risk than patients without. In multivariate logistic analysis, HPS of SLEs (odds ratio [OR] = 1.54, 95% confidence interval [CI] 1.16-2.05, P = 0.003) and depressive symptoms (OR = 1.08, 95% CI 1.05-1.11, P < 0.001) were associated with suicidal risk even after adjustment of gender, age, marriage, drinking behavior, and childless.</p><p><b>Conclusions</b>HPS of SLEs is associated with suicide risk in Chinese patients with MDD. Further suicide prevention programs targeting this risk factor are needed.</p><p><b>Trial Registration</b>ClinicalTrials.gov NCT02023567; https//clinicaltrials.gov/ct2/show/NCT02023567?term=NCT02023567&rank=1.</p>
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Psychiatric Status Rating Scales / Psychology / Suicide / Bipolar Disorder / Logistic Models / Odds Ratio / Epidemiology / Risk Factors / Asian People / Depressive Disorder, Major Type of study: Etiology study / Prognostic study / Risk factors Limits: Adolescent / Adult / Female / Humans / Male Language: English Journal: Chinese Medical Journal Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Psychiatric Status Rating Scales / Psychology / Suicide / Bipolar Disorder / Logistic Models / Odds Ratio / Epidemiology / Risk Factors / Asian People / Depressive Disorder, Major Type of study: Etiology study / Prognostic study / Risk factors Limits: Adolescent / Adult / Female / Humans / Male Language: English Journal: Chinese Medical Journal Year: 2018 Type: Article