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Immune Homeostasis: Effects of Chinese Herbal Formulae and Herb-Derived Compounds on Allergic Asthma in Different Experimental Models / 中国结合医学杂志
Chinese journal of integrative medicine ; (12): 390-398, 2018.
Article in English | WPRIM | ID: wpr-687907
ABSTRACT
Allergic asthma is thought to arise from an imbalance of immune regulation, which is characterized by the production of large quantities of IgE antibodies by B cells and a decrease of the interferon-γ/interleukin-4 (Th1/Th2) ratio. Certain immunomodulatory components and Chinese herbal formulae have been used in traditional herbal medicine for thousands of years. However, there are few studies performing evidence-based Chinese medicine (CM) research on the mechanisms and effificacy of these drugs in allergic asthma. This review aims to explore the roles of Chinese herbal formulae and herb-derived compounds in experimental research models of allergic asthma. We screened published modern CM research results on the experimental effects of Chinese herbal formulae and herb-derived bioactive compounds for allergic asthma and their possible underlying mechanisms in English language articles from the PubMed and the Google Scholar databases with the keywords allergic asthma, experimental model and Chinese herbal medicine. We found 22 Chinese herb species and 31 herb-derived anti-asthmatic compounds as well as 12 Chinese herbal formulae which showed a reduction of airway hyperresponsiveness, allergen-specifific immunoglobulin E, inflflammatory cell infifiltration and a regulation of Th1 and Th2 cytokines in vivo, in vitro and ex vivo, respectively. Chinese herbal formulae and herbderived bioactive compounds exhibit immunomodulatory, anti-inflflammatory and anti-asthma activities in different experimental models and their various mechanisms of action are being investigated in modern CM research with genomics, proteomics and metabolomics technologies, which will lead to a new era in the development of new drug discovery for allergic asthma in CM.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Asthma / Drugs, Chinese Herbal / Therapeutic Uses / Disease Models, Animal / Drug Therapy / Allergy and Immunology / Homeostasis / Hypersensitivity / Immunologic Factors Type of study: Prognostic study Limits: Animals Language: English Journal: Chinese journal of integrative medicine Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Asthma / Drugs, Chinese Herbal / Therapeutic Uses / Disease Models, Animal / Drug Therapy / Allergy and Immunology / Homeostasis / Hypersensitivity / Immunologic Factors Type of study: Prognostic study Limits: Animals Language: English Journal: Chinese journal of integrative medicine Year: 2018 Type: Article