Landscape of PD-1/PD-L1 Regulation and Targeted Immunotherapy / 中国医学科学杂志(英文版)
Chinese Medical Sciences Journal
;
(4): 174-182, 2018.
Article
in English
| WPRIM
| ID: wpr-687934
ABSTRACT
Programmed cell death protein 1 (PD-1)/programmed death ligand 1 (PD-L1) is a significant immune checkpoint, and the dysfunction of this axis contributes to tumor metastasis and immune escape. PI3K/Akt/mTOR and MAPK signal network induces PD-1/PD-L1 expression and facilitates tumor progression. Transcriptional factors such as hypoxia induced factors, PTEN, p53, CDK5, BRD4, STAT modulate PD-1/PD-L1 expression. PD-1/PD-L1 level is also regulated via epigenetic and post-translational manner. The underlying mechanisms mentioned above may provide potential targets for tumor treatment. At present, the combination therapy of PD-1/PD-L1 monoclonal antibodies plus small molecular inhibitors has achieved good outcomes in tumor treatment.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
English
Journal:
Chinese Medical Sciences Journal
Year:
2018
Type:
Article
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