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Association of programmed cell death 1 (PDCD1) gene polymorphisms with colorectal cancer among Han Chinese population / 中华医学遗传学杂志
Article in Chinese | WPRIM | ID: wpr-687974
Responsible library: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To assess the association of programmed cell death 1 (PDCD1) gene polymorphisms with the susceptibility and/or progression of colorectal cancer.</p><p><b>METHODS</b>A hospital-based case-control study was carried out, which recruited 426 colorectal cancer patients and 500 healthy individuals. Five single nucleotide polymorphisms, namely rs36084323, rs11568821, rs2227981, rs2227982 and rs10204525, were selected for the study and genotyped with a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay.</p><p><b>RESULTS</b>The G allele of rs36084323 under a dominant model was associated with increased risk of advanced TNM staging of colorectal cancer progression (OR=1.59, 95%CI=1.02-2.48). Haplotypes G-G-C-T-A and A-G-C-C-G of the rs36084323, rs11568821, rs2227981, rs2227982, and rs10204525 were negatively associated with the occurrence of colorectal cancer.</p><p><b>CONCLUSION</b>The G allele of rs36084323 is associated with increased risk of advanced TNM staging of colorectal cancer. Conversely, the incidence of colorectal cancer is negatively associated with the haplotypes G-G-C-T-A and A-G-C-C-G of rs36084323, rs11568821, rs2227981, rs2227982, and rs10204525.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Haplotypes / Humans / Colorectal Neoplasms / Case-Control Studies / China / Genetic Predisposition to Disease / Polymorphism, Single Nucleotide / Asian Continental Ancestry Group / Ethnology Country/Region as subject: Asia Language: Chinese Journal: Chinese Journal of Medical Genetics Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Haplotypes / Humans / Colorectal Neoplasms / Case-Control Studies / China / Genetic Predisposition to Disease / Polymorphism, Single Nucleotide / Asian Continental Ancestry Group / Ethnology Country/Region as subject: Asia Language: Chinese Journal: Chinese Journal of Medical Genetics Year: 2018 Type: Article