Association of polymorphisms of NAPE-PLD and FAAH genes with schizophrenia in Chinese Han population / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 215-218, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-687975
ABSTRACT
<p><b>OBJECTIVE</b>To assess the association of polymorphisms of N-acyl-phosphatidylethanolamine-phospholipase D (DAPE-PLD) and fatty acid amide hydrolase (FAAH) genes, as well as their interaction, with schizophrenia.</p><p><b>METHODS</b>Polymorphisms of NAPE-PLD rs12540583 and FAAH rs324420, rs2295633, and rs6429600 were determined with PCR - restriction fragment length polymorphism assay and Sanger sequencing. The genotypes of 345 subjects of Han Chinese origin diagnosed with schizophrenia and a 403 controls were compared. The results were analyzed with SPSS 17.0, and the interaction of the two genes was analyzed using a multifactor dimensionality reduction (MDR) method.</p><p><b>RESULTS</b>The frequency of NAPE-PLD rs12540583 polymorphism was significantly different between the two groups under both dominant and additive models (χ2=17.18 vs. χ2=18.94, P<0.0125). The frequencies of AC genotype and C allele of the patient group at rs12540583 were higher than those of the controls, and the interaction of NAPE-PLD and FAAH was associated with schizophrenia. A four-loci model (rs12540583, rs324420, rs2295633 and rs6429600) can best model the interaction between NAPE-PLD and FAAH.</p><p><b>CONCLUSION</b>The AC genotype and C allele of NAPE-PLD rs12540583 locus are risk factors for schizophrenia, and the interaction between NAPE-PLD rs12540583 and FAAH rs324420, rs2295633 and rs6429600 is associated with schizophrenia.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phospholipase D
/
Polymorphism, Genetic
/
Schizophrenia
/
China
/
Asian People
/
Ethnology
/
Amidohydrolases
/
Genetics
/
Genotype
Type of study:
Prognostic study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2018
Type:
Article
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