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Association of OSMR gene polymorphisms with dilated cardiomyopathy in a Han Chinese population / 中华医学遗传学杂志
Chinese Journal of Medical Genetics ; (6): 210-214, 2018.
Article in Chinese | WPRIM | ID: wpr-687976
ABSTRACT
<p><b>OBJECTIVE</b>To assess the association of polymorphisms of oncostatin M receptor (OSMR) gene with dilated cardiomyopathy (DCM) in a Han Chinese population.</p><p><b>METHODS</b>For 351 DCM patients and 418 healthy controls, two single nucleotide polymorphisms (SNPs) of the OSMR gene, namely rs2292016 (promoter, -100G/T) and rs2278329 (missense, Asp553Asn), were genotyped with a TaqMan SNP genotyping assay. Two hundred of the patients were also followed up for (49.85 ± 22.52) months.</p><p><b>RESULTS</b>For rs2292016, carriers of GT genotype were more likely to develop DCM compared to those with GG and TT genotypes (OR=1.45, 95%CI 1.09-1.92, P=0.01). For those who did not receive cardiac resynchronization therapy, the GG genotype of rs2292016 was an independent indicator for poor prognosis (OR=1.69, 95%CI 1.11-2.63, P=0.017). No association was found between genotypes of rs2278329 with the susceptibility or prognosis of DCM.</p><p><b>CONCLUSION</b>Polymorphisms of the OSMR rs2292016 locus are related to the development and outcome of DCM.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Cardiomyopathy, Dilated / China / Polymorphism, Single Nucleotide / Asian People / Ethnology / Oncostatin M Receptor beta Subunit / Genetics / Genotype Limits: Humans Country/Region as subject: Asia Language: Chinese Journal: Chinese Journal of Medical Genetics Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Cardiomyopathy, Dilated / China / Polymorphism, Single Nucleotide / Asian People / Ethnology / Oncostatin M Receptor beta Subunit / Genetics / Genotype Limits: Humans Country/Region as subject: Asia Language: Chinese Journal: Chinese Journal of Medical Genetics Year: 2018 Type: Article