Local injection of exogenous nerve growth factor improves early bone maturation of implants / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 128-132, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-688050
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of nerve growth factor (NGF) in the osteogenic action of implants and the maturation and reconstruction changes in bone tissues in the early stage of osseointegration.</p><p><b>METHODS</b>The mouse implant model was established by placing titanium in the femoral head of the mouse and locally injecting NGF in the implant zone. On 1, 2 and 4 weeks after operation, stain samples were collected from animals using hematoxylin-eosin (HE) staining and Masson staining. The effect of NGF on the bone maturation was compared at different time points of early stage osseointegration.</p><p><b>RESULTS</b>The results of HE and Masson staining indicated that the local injection of external NGF can up-regulate bone mass, amount of bone trabecula, and bone maturity in the mouse model. The mature bone rate in treatment group of 1 week and 4 weeks after operation were significantly higher than those in the control group (P<0.05).</p><p><b>CONCLUSIONS</b>NGF can shorten the period of bone maturation.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
West China Journal of Stomatology
Year:
2018
Type:
Article
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