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Cytogenetic Analysis in Spontaneous Abortion / 대한주산의학회잡지
Article in Korean | WPRIM | ID: wpr-68815
Responsible library: WPRO
ABSTRACT
OBJECT To analyze the frequency and the types of chromosomal abnormalities in conceptus of spontaneous abortion

method:

81 cases of products of conception aborted spontaneously were collected From Nov. 1999 to May, 2004 in the cytogenetic laboratory at Kangnam St. Mary's Hospital, Catholic University Medical College. The cytogenetic results,along with clinical information including gestational age at the time of the miscarriage and maternal age, were compiled in a database.

RESULTS:

Cytogenetic results were obtained from 76 cases (93.8%), of which 33 cases (43.4%) showed chromosome abnormalities. Of 33 chromosomal abnormalities, 12 cases (36.4%) showed monosomy X, including one case of 46,X,+7 and the other case of 44,X, t(13q14q). Autosomal trisomy was also detected in 12 cases (36.4%). The most frequent autosomal trisomy was that of chromosome 18 (4 cases), which occurred exclusively in old maternal age (37.8+/-7.5 years old). Mosaicism was found in 2 cases. Triploidy was identified in 4 cases. Structural abnormalities were identified in 3 cases.

CONCLUSION:

This study showed that monosomy X and trisomy were the most common chromosomal abnormalities in spontaneous abortion, and autosomal trisomy was dependant on maternal age.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Trisomy / Turner Syndrome / Chromosomes, Human, Pair 18 / Female / Humans / Pregnancy / Abortion, Spontaneous / Chromosome Aberrations / Gestational Age / Maternal Age Language: Korean Journal: Korean Journal of Perinatology Year: 2005 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Trisomy / Turner Syndrome / Chromosomes, Human, Pair 18 / Female / Humans / Pregnancy / Abortion, Spontaneous / Chromosome Aberrations / Gestational Age / Maternal Age Language: Korean Journal: Korean Journal of Perinatology Year: 2005 Type: Article