Influence of combination therapy on the oxygen saturation of retinal vessels and serum Apelin in patients with diabetic retinopathy / 国际眼科杂志(Guoji Yanke Zazhi)

ABSTRACT

@#AIM:To explore the influence of compound anisodine combined with triamcinolone acetonide on the oxygen saturation of retinal vessels and serum Apelin in patients with diabetic retinopathy(DR). <p>METHODS:Totally 58 cases of patients(60 eyes)with diabetic retinopathy from June 2014 to December 2016 in our hospital were selected as the research object. All of them were randomly divided into control group(29 cases, 30 eyes)and observation group(29 cases, 30 eyes). The control group received panretinal photocoagulation; the observation group was given intravitreal injection of triamcinolone acetonide before panretinal photocoagulation combined with compound anisodine after panretinal photocoagulation. After treatment, the postoperative visual recovery and the complications were recorded. The oxygen saturation of retinal vessels and the serum levels of Apelin of the two groups were analyzed and compared as well. <p>RESULTS:After the treatment, the visual acuity of the two groups increased significantly, the proportion of vision improvement in the observation group(90%)was significantly higher than that in the control group(67%, <i>P</i><0.05). The mean sensitivities of visual field in the observation group in 1d,1mo and 2mo after photocoagulation were significantly higher than those in the control group(<i>P</i><0.05). Compared with the before treatment, the oxygen saturation of retinal vessels had decreased after treatment in both groups, that in observation group was significantly higher than control group(<i>P</i><0.05). Compared with the before treatment, the level of Apelin had decreased after treatment in both groups, the Apelin levels was significantly lower in observation group than control group(<i>P</i><0.05). The complication rate in the observation group was 3% while the complication rate in the control group was 17%, no difference was found on the incidence of complication between the observation group and control group(<i>P</i>=0.109). <p>CONCLUSION:The implementation of intravitreal injection of triamcinolone acetonide combined with the injection of compound anisodine <i>via</i> temporal subcutaneous tissue for patients with diabetic retinopathy is significantly effective, it can effectively reduce the level of the Apelin to inhibit the proliferation of retinal vessels, relieve the ischemic and hypoxia injury, which benefits the postoperative vision recovery with high safety.