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Predictive value of cord blood 25(OH)D3 for early infantile atopic dermatitis / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics ; (12): 303-307, 2018.
Article in Chinese | WPRIM | ID: wpr-689636
ABSTRACT
<p><b>OBJECTIVE</b>To explore the predictive value of cord blood 25(OH)D [25(OH)D] for infantile atopic dermatitis (AD), and to provide a reference for primary prevention of early infantile AD.</p><p><b>METHODS</b>The neonates born from July to September, 2015 were enrolled. The cord blood samples were collected at birth to measure the level of 25(OH)D. Outpatient follow-up was conducted for all the infants at 6 weeks, 3 months, and 6 months after birth. A survey was performed to investigate the incidence of AD.</p><p><b>RESULTS</b>A total of 67 neonates completed a 6-month follow-up. The incidence of AD was 34% (23/67), and 91% (21/23) of these cases occurred in the first month after birth. The 23 AD children had a significantly lower cord 25(OH)D level than those without AD (P<0.05). The children with a cord 25(OH)D level <30 nmol/L showed a significantly higher incidence of AD than those with a cord 25(OH)D level ≥30 nmol/L (P<0.05). The receiver operating characteristic (ROC) analysis showed that the area under the ROC curve of cord 25(OH)D in predicting AD was 0.648 (standard error 0.075; 95%CI 0.502-0.795). Its sensitivity, specificity, positive predictive value, and negative predictive value were 52.2%, 79.5%, 57.1%, and 76.1%, respectively. Logistic regression analysis showed that low cord 25(OH)D level, preference for seafood during pregnancy, atopic family history, and mixed feeding were risk factors for infantile AD (P<0.05).</p><p><b>CONCLUSIONS</b>Cord 25(OH)D level is inversely associated with the risk of infantile AD, but it has a low diagnostic value for this disease.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Blood / Calcifediol / Logistic Models / Chemistry / Epidemiology / Predictive Value of Tests / Risk Factors / ROC Curve / Dermatitis, Atopic / Fetal Blood Type of study: Etiology study / Prognostic study / Risk factors Limits: Female / Humans / Male / Infant, Newborn Language: Chinese Journal: Chinese Journal of Contemporary Pediatrics Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Blood / Calcifediol / Logistic Models / Chemistry / Epidemiology / Predictive Value of Tests / Risk Factors / ROC Curve / Dermatitis, Atopic / Fetal Blood Type of study: Etiology study / Prognostic study / Risk factors Limits: Female / Humans / Male / Infant, Newborn Language: Chinese Journal: Chinese Journal of Contemporary Pediatrics Year: 2018 Type: Article