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Relationship between expression of peripheral blood HLA-DR, CD4CD25 regulatory T cells, IL-17 and IL-27 with liver damage in children with human cytomegalovrius infection / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics ; (12): 554-558, 2018.
Article in Chinese | WPRIM | ID: wpr-690133
ABSTRACT
<p><b>OBJECTIVE</b>To study the relationship between the expression of peripheral blood HLA-DR, CD4CD25 regulatory T cells, IL-17 and IL-27 with liver damage in children with human cytomegalovirus (HCMV) infection.</p><p><b>METHODS</b>Twenty-one HCMV children with liver damage and twenty-one HCMV children without liver damage were enrolled in this study. The expression of peripheral blood HLA-DR and CD4CD25 regulatory T cells was detected by flow cytometry. Plasma levels of IL-17 and IL-27 were measured using ELISA.</p><p><b>RESULTS</b>The plasma levels of IL-17 and IL-27 in children with liver damage were significantly higher than in those without liver damage, while the expression of peripheral blood CD4CD25 regulatory T cells was lower than in those without liver damage (P<0.05). Plasma IL-17 and IL-27 levels were negatively correlated with the expression of peripheral blood CD4CD25 regulatory T cells (P<0.01).</p><p><b>CONCLUSIONS</b>Immune imbalance mediated by CD4CD25 regulatory T cells and over-expression of IL-17 and IL-27 may be involved in the pathogenesis of liver damage in children with HCMV infection.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Physiology / Wounds and Injuries / Blood / HLA-DR Antigens / CD4 Antigens / Interleukins / T-Lymphocytes, Regulatory / Cytomegalovirus Infections / Interleukin-17 / Cytomegalovirus Limits: Female / Humans / Infant / Male Language: Chinese Journal: Chinese Journal of Contemporary Pediatrics Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Physiology / Wounds and Injuries / Blood / HLA-DR Antigens / CD4 Antigens / Interleukins / T-Lymphocytes, Regulatory / Cytomegalovirus Infections / Interleukin-17 / Cytomegalovirus Limits: Female / Humans / Infant / Male Language: Chinese Journal: Chinese Journal of Contemporary Pediatrics Year: 2018 Type: Article