Advances of long-acting recombinant protein therapeutics / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 360-368, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-690166
ABSTRACT
Some of the recombinant protein therapeutics with short half-life requires high frequent dose or injection, which results in poor patient compliance. This challenge has prompted the development of long-acting recombinant proteins in recent years. Four strategies and methods, including chemical modification, protein engineering, fusion proteins and protein glycosylation are used to modify protein molecule and finally obtain improved pharmacokinetics (PK) properties. This article reviews the four strategies of half-life extension and presents a detailed list of long-acting therapeutics on US, EU and China markets.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2018
Type:
Article
Similar
MEDLINE
...
LILACS
LIS