Relationship between Autophagy and Curcumin-induced Anticancer Effect / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 568-572, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-690294
ABSTRACT
Curcumin is a polyphenol extracted from turmeric rhizome and has multiple pharmacological roles. Recently,its anticancer properties have been recognized. Also,curcumin regulates autophagy in tumor cells via signaling pathways including AMP-activated protein kinase,mammalian target of rapamycin,transcription factor EB,Beclin-1,B-cell lymphoma 2,and endoplasmic reticulum stress. Considering the complicated crosstalk between autophagy and apoptosis,in this article we summaize the mechanism of curcumin-induced autophagy and its effect on apoptosis,with an attempt to provide insights on tumor therapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2018
Type:
Article
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