The Effect of Nitric Oxide on Mechanical and Theraml Allodynia in Neuropathic Pain Model of Rat
Journal of the Korean Neurological Association
;
: 283-288, 2003.
Article
in Korean
| WPRIM
| ID: wpr-69036
ABSTRACT
BACKGROUND:
Nitric oxide (NO) is known to play causative role in the development of neuropathic pain following peripheral nerve injury. However, it is yet to be investigated whether the role of NO differs in pain modalities, such as mechanical and thermal stimuli. Also, it has not been investigated whether NO has different roles in the stages of neuropathic pain - its development and maintenance.METHODS:
Neuropathic pain was induced by a resection of the lumbar dorsal root 5, 6 (L 5, 6). After N-nitro-L-arginine methyl ester (L-NAME), an NO synthase inhibitor was injected intrathecally or locally around the dorsal root, we observed the behavioral response to the mechanical and thermal stimuli.RESULTS:
Mechanical and thermal allodynia was inhibited by the application of L-NAME before the dorsal root injury. However, L-NAME did not affect the mechanical and thermal allodynia during the maintenance of neuropathic pain.CONCLUSIONS:
We suggest that NO in the spinal cord or injured perineural site may play an important role in the induction of neuropathic pain, and may be associated with mechanical and thermal allodynia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Spinal Cord
/
Spinal Nerve Roots
/
Nitric Oxide Synthase
/
NG-Nitroarginine Methyl Ester
/
Peripheral Nerve Injuries
/
Hyperalgesia
/
Neuralgia
/
Nitric Oxide
Limits:
Animals
Language:
Korean
Journal:
Journal of the Korean Neurological Association
Year:
2003
Type:
Article
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