MMP Inhibitor Ilomastat Improves Survival of Mice Exposed to γ-Irradiation / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 467-472, 2018.
Article
in English
| WPRIM
| ID: wpr-690633
ABSTRACT
There is still a need for better protection against or mitigation of the effects of ionizing radiation following conventional radiotherapy or accidental exposure. The objective of our current study was to investigate the possible roles of matrix metalloproteinase inhibitor, ilomastat, in the protection of mice from total body radiation (TBI), and the underlying protective mechanisms. Ilomastat treatment increased the survival of mice after TBI. Ilomastat pretreatment promoted recovery of hematological and immunological cells in mice after 6 Gy γ-ray TBI. Our findings suggest the potential of ilomastat to protect against or mitigate the effects of radiation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Radiation Effects
/
Radiation Injuries, Experimental
/
Radiation-Protective Agents
/
Spleen
/
Blood
/
Blood Cells
/
Survival Analysis
/
Whole-Body Irradiation
/
Therapeutic Uses
/
Dose-Response Relationship, Drug
Limits:
Animals
Language:
English
Journal:
Biomedical and Environmental Sciences
Year:
2018
Type:
Article
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